Clinical observation on effects of simvastatin combined with aspirin in treatment of acute ischemic stroke

Abstract

Objective To explore the clinical effects of simvastatin combined with aspirin in treatment of acute ischemic stroke (AIS).Methods From December 2010 to December 2011 98 patients with AIS treated in our hospital were randomly divided into simvastatin group and combination treatment group,simvastatin group only received simvastatin treatment,combination treatment group used simvastatin treatment based on given aspirin treatment,the clinical efficacy was compared in patients of two groups.Results After treatment by groups,29 cases,effective in 12 cases,8 cases were invalid,the total efficiency was 83.67％;the combination treatment group 33 cases,effective in 14 cases,2 cases were invalid,the total efficiency rate was 95.92％.The total effective rate in combination treatment group was significantly higher than that of simvastatin group,with statistical significant difference (x 2=25.14,P＜0.05).Conclusion Simvastatin treatment combined with aspirin therapy in treating patients with AIS can significantly improve the clinical treatment effect,which is worth popularizing. Key words: Simvastatin; Aspirin; Combination; Acute cerebral ischemic stroke (AIS)