Clinical observation on carbon dioxide fractional laser combined with liquid nitrogen cryotherapy for flat warts

Abstract

Objective To evaluate the clinical efficacy and safety about carbon dioxide fractional laser combined with liquid nitrogen cryotherapy for flat warts.Methods Eighty-three patients with flat warts were divided into 2 groups according to the treatment method,42 patients in treatment group were treated by carbon dioxide fractional laser combined with liquid nitrogen cryotherapy,41 patients in control group were treated by liquid nitrogen cryotherapy alone.As a period for 10 days,2 groups were given 2 periods of treatment.The therapeutic effect,recurrence rate and adverse reaction were compared between 2 groups.Results The cure rates of 1-period and 2-period in treatment group were significantly higher than those in control group [73.81％(31/42) vs.46.34％(19/41) and 97.62％(41/42) vs.75.61％(31/41)],the recurrence rate and incidence of adverse reaction in treatment group were significantly lower than those in control group [2.44％(1/41) vs.19.35％(6/31) and 9.52％(4/42) vs.31.71％(13/41)],there were statistical differences (P ＜ 0.05 or ＜ 0.01).Conclusion Carbon dioxide fractional laser combined with liquid nitrogen cryotherapy for fiat warts is a safe and effective treatment with low recurrence rate. Key words: Warts; Carbon dioxide; Lasers; Liquid nitrogen cryotherapy