Abstract
Objective: The present study aimed to analyze the risk factors correlated with overactive bladder (OAB), observe the effects of desloratadine in the treatment of OAB, and explore the correlation between OAB and atopic constitution in children.Methods: Correlation and binary logistic regression analysis of the medical data from 447 children clinically diagnosed with OAB from June 2019 to June 2020 were conducted. The data included a history of urticaria, eczema, itchy skin, and allergic rhinitis or allergic cough. The OABSS scores before and after treatment with desloratadine were compared to evaluate the effectiveness of desloratadine for OAB.Results: The risk factors for OAB in children included eczema, allergic rhinitis or allergic cough, itchy skin, and the levels of total blood IgE. Desloratadine was 96.5% effective in treating cases with risk factors including eczema, allergic rhinitis or allergic cough, and itchy skin. There existed statistical significance in the difference in OABSS scores before and after the treatment of desloratadine (P < 0.05).Conclusion: OAB in children was correlated with atopic manifestations such as eczema, itchy skin, allergic rhinitis, or allergic cough. Desloratadine was safe and effective in the treatment of OAB in children with atopic manifestations.
Highlights
Overactive bladder (OAB) is one of the most common lower urinary tract symptoms in children
A total of 447 cases with OAB were enrolled in the present study, including 232 males and 215 females with an average age of 6.40 ± 2.41
117 with detrusor hyperactivity + bladder hypersensitivity met the typical results in the urodynamics of OAB
Summary
Overactive bladder (OAB) is one of the most common lower urinary tract symptoms in children. OAB is defined by the International Children Continence Society (ICCS) as a type of urinary urgency, usually accompanied by symptoms of frequent urination and nocturia, with or without urge incontinence, and without urinary tract infection or other definite pathological changes [1]. According to the symptom assessment tool for overactive bladder syndrome–overactive bladder symptom score (OABSS), urinary urgency ≥2 points and total score ≥3 points were diagnosed as OAB [2]. Clinical studies have shown that patients with OAB can sense bladder fullness, urge to urinate and pain more keenly than healthy people. OAB is characterized by anaphylaxis or enhanced bladder sensation, which is more pronounced in interstitial cystitis [3, 4]. A study of 178 children with asthma by Soyer et al found that asthmatic
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