Clinical observation of reoperation or percutaneous radiofrequency ablation in the treatment of patients with recurrent hepatocellular carcinoma

Abstract

Objective To investigate the clinical efficacy and survival of patients with recurrent hepatocellular carcinoma underwent reoperation or percutaneous radiofrequency ablation(PRFA). Methods Retrospective analysis were performed in 58 patients with recurrent hepatocellular carcinoma from January 2011 to May 2013, among whom 25 patients underwent reoperation, while 33 patients received PRFA Statistical analysis were performed by using SPSS18.0 software. Measurement data, such as biochemical indicators, were expressed as ±s, and were examined by using t test. Count data such as postoperative complications and survival were examined by chi square test. A P value <0.05 was considered as statistically significant difference. Results There were statistically significant differences in terms of TBIL, ALT, ALB and GGT between 2 groups(P<0.05) and better outcome were achieved in PRFA group. In terms of postoperative complications, better outcome were achieved in PRFA group (10cases) compared with reoperation group (34 cases), with statistically significant difference (P<0.05). The recurrence rate of 9.1% and disease-free survival rate of 84.8% in PRFA group were significantly better than 28.0% and 56.0% in reoperation group respectively, with statistically significant difference (P<0.05). Conclusions Compared with reoperation, better clinical outcome could be achieved by PRFA treatment for patients with recurrent hepatocellular carcinoma, including better preservation of liver function and lower tumor recurrence rate and longer disease-free survival. Key words: Carcinoma, Hepatocellular; Hepatectomy; Reoperation; Catheter Ablation; Recurrence