Abstract
Objectives:To investigate the clinical effect of mild hypothermia combined with intravenous thrombolysis in the treatment of acute cerebral infarction.Methods:Eighty-eight patients with acute cerebral infarction in Binzhou People’s Hospital between May 2018 and August 2019 were randomly selected and divided into a control group and an observation group according to the random number table method, with 44 patients in each group. The control group was given intravenous thrombolysis; the observation group was treated with mild hypothermia (30-35°C) in addition to intravenous thrombolytic thrombolysis. The clinical efficacy, incidence of complications, oxidative stress indexes, inflammatory factor level, neurological function, and mental state of the two groups before and after treatment were compared.Results:The clinical efficacy of the observation group was significantly better than that of the control group, and the difference was statistically significant (P<0.05). There was no significant difference in the levels of oxidative stress indexes and inflammatory factors between the two groups before treatment (P<0.05). After treatment, the levels of oxidative stress indexes and inflammatory factors of the two groups significantly improved, and the improvement of the observation group was better than that of the control group; the differences were statistically significant (P<0.05). There was no significant difference in the neurological function and mental state between the two groups before treatment (P<0.05). After treatment, the neurological function and mental state of the two groups significantly improved, and the improvement of the observation group was better than that of the control group; the differences were statistically significant (P<0.05). There was no significant difference in the incidence of complications and mortality between the two groups (P>0.05).Conclusion:Thrombolytic therapy combined with mild hypothermia has a good efficacy in the treatment of acute cerebral infarction. The therapy can improve the neurological function of patients with acute cerebral infarction by significantly improving the oxidative stress index and relieving the inflammatory reaction. Its efficacy is better than single thrombolytic therapy.
Highlights
Research results in China and abroad have confirmed that mild hypothermia treatment has a protective effect on brain cells, and mild hypothermia treatment is conducive to the recovery of neurological function and the improvement of prognosis for patients with acute cerebral infarction.[7,8]
There was no significant difference in neurological function and mental state between the two groups before treatment
The results of this study showed that the total clinical efficacy of the observation group was significantly higher than that of the control group, and the post-treatment neurological function score of the observation group was significantly lower than that of the control group, which verified that recombinant tissue plasminogen activator (rt-PA) intravenous thrombolysis combined with mild hypothermia treatment could significantly improve the neurological deficit of patients, and the findings were consistent with the research results of Hu et al.[22]
Summary
Acute cerebral infarction is a clinical syndrome of neurologic impairment caused by cerebral ischemia and hypoxia, with a high mortality and disability rate; it is a common emergency and severe disease.[1,2] At present, intravenous thrombolytic therapy within the time window has been written into thePak J Med Sci November - December 2021 Vol 37 No 7 www.pjms.org.pk 1813 diagnosis and treatment guidelines as class I recommendation by many countries, which is one of the most effective methods for the treatment of acute cerebral infarction.[3,4] with the extensive development of clinical treatment, it has been found that patients with acute cerebral infarction are prone to a series of adverse reactions and complications after receiving intravenous thrombolytic therapy.[5]. Acute cerebral infarction is a clinical syndrome of neurologic impairment caused by cerebral ischemia and hypoxia, with a high mortality and disability rate; it is a common emergency and severe disease.[1,2] At present, intravenous thrombolytic therapy within the time window has been written into the. This study observed the clinical efficacy of intravenous thrombolysis combined with mild hypothermia in the treatment of patients with acute cerebral infarction and its effect on oxidative stress reaction, to provide more clinical treatment references for patients with acute cerebral infarction
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
