Clinical observation of corboprost in preventing postpartum hemorrhage of caserean in high risk pregnancy

Abstract

Objective To observe the efficacy of corboprost combined with oxytocin on preventing hemorrhage during and after cesarean section in high risk pregnancy.Methods Ninety high risk patients hospitalized for cesarean section with probability of postpartum hemorrhage in our hospital from September 2008 to June 2010 were choosed including 16 case of placenta previa,38 case of macrosomia,24 case of polyhydramnios,and 12 case of twins.They were randomly divided into two groups:45 case in the observation group recieued corboprost plus oxytocin,and 45 case in the control group recleued oxytocin.In observation group,after the delivery of the fetus head,corboprost 1 mg sublingual administration,oxytocin 20 IU uterus body injection,and 20 IU intravenous injection at dripping speed 80 drops/minute was incidence.In control group,after the delivery of fetus,oxytocin 20 IU uterus myometrium injection,and 20 IU intravenous injection at dripping speed 80 drops/minute was giuen.The bleeding volumes of the two groups during,two hours after and 24 hours after cesarean were compared.Results The bleeding volumes of the observation group during,2 hours after and 24 hours after operation were obviously less than these of the control group.The incidence of postpartum hemorrhage was also lower in odxeruation group.The differences were significant between the groups (P ＜ 0.05).Conclusions Corboprost plus oxytocin is recommended because it promotes postpartum uterus contraction better than single use of oxytocin,cansignificantly reduce the bleeding volume during and after cesarean operation,and its medication is simple,safe and reliable. Key words: Corboprost ; High-risk pregnancy ; Cesarean section ; Postpartum hemorrhage