Clinical observation of botulinum toxin type A fortreatment of blepharospasm and Meige syndrome

Abstract

Objective To explore the efficacy of botulinum toxin type A (BOTOX-A) for treatment of blepharospasm and Meige syndrome. Methods Local multi-point injection of BOTOX-A was performed for 32 patients of blepharospasm and Meige syndrome. The efficacy and side effects were compared between the results before and after injection. Results Symptoms of 62.5% of the patients were completely relieved,34.4% were obviously relieved,3.1% were partially relieved. The average of therapeutic efficacy lasted 3 to 6 monthes.It was effective to the recurrent patients repeated with injection.Local untoward effect was light and transient. Conclusions Local injection of BOTOX-A is a simple,effective and safe therapy for blepharospasm and Meige syndrome. Key words: Botulinum toxin type A ; Blepharospasm ; Meige syndrome ; Therapeutic efficacy ;