Clinical observation of 61 single kidney transplants with donors from infants and young children to adults

Abstract

Objective To evaluate the growth and survival of single kidney transplants with donation after citizen death (DCD) donors from infants and children (<3 years of age) to adults. Methods We retrospectively analyzed the data of single kidney transplants with donors from infants and young children to adults in our center. All the recipients were divided into infant donor group (≤3 years of age) and children donor group (1 year< age ≤3 years) in terms of the donor’s age. The serum creatinine (SCr) level after surgery was determined and the major diameter of the kidney was measured by Doppler B ultrasonography. DGF, vascular complications, urinary tract complications, proteinuria, acute rejection, and infection were recorded during the follow-up period. Results There were 24 cases in infant donor group and 37 in children donor group. The mean follow-up period was 28 months. The SCr level at 1st month post-transplantation was significantly higher in infant donor group than in children donor group (350.67±35.57 μmol/L versus 193.70±86.76 μmol/L), and the major diameter (±s) of the kidney in children donor group was significantly greater than that in infant donor group (78.29±4.68 mm versus 93.62±5.57 mm), but there was no significant difference during the subsequent 3-year follow-up period. The incidence of DGF in infant donor group was significantly higher than in children donor group, but there was significant difference in the rate of vascular complications, urinary tract complications, proteinuria, acute rejection, and infection between two groups. Conclusion The single kidney transplants from infants and young children to adults can grow rapidly, and their survival rate is relatively high. Key words: infants and young children donor; single kidney transplant; adult recipients