Clinical observation for application of compound Danshen dropping pills after finger replantation

Abstract

Objective To observe the effect of compound Danshen dropping pills on the activated partial thromboplastin time (APTT) of the patients after finger replantation. Methods A total of 50 cases with finger replantation were randomly divided into two groups with 25 in each: experimental group and control group. After the replantation, anticoagulant therapy was conducted in experimental group with oral compound Danshen dropping pills and in control group with intravenous heparin sodium. APTT, survival rate and vascular crisis incidence rate were compared between two groups. Results All the replanted fingers from two groups survived with the survival rate being 100%. One case from experimental group had vascular crisis with the incidence rate being 4% and no vascular crisis occurred in control group. At 3 days after the replantation, the APTT of control group was longer than that of experimental group (t=16.506, P=0.000<0.05). At 10 days after the replantation, the APTT of control group was still longer than that of experimental group (t=12.300, P=0.000<0.05). Conclusion The compound Danshen dropping pills can exert less effect on APTT in order to avoid the APTT extension induced by heparin sodium after replantation. To some extent, it can be used as alternative medicine of heparin sodium for anticoagulant therapy after replantation, but large sample studies are still necessary to confirm the research outcome. Key words: Replantation; Treatment outcome; Activated partial thromboplastin time; Compound Danshen dropping pills