Clinical observation and effects on endocrine of the recipe of invigorating kidney for regulating menstruation combined with leptosome in the treatment of polycystic ovary syndrome ovulation disorders

Abstract

Objective To determine the recipe of invigorating kidney for regulating menstruation combined with curved repairing in the treatment of polycystic ovary syndrome(PCOS) ovulation disorder related outcome measures, and to evaluate the clinical curative effect of the therapy. Methods Sixty-eight cases of PCOS ovulation disorder patients were randomly selected and randomly divided into the pure western medicine treatment control group and integrated traditional Chinese and Western medicine treatment of the observation group, each group had 34 cases.The control group patients were given oral progestin capsule with 0.2 g/time, 1 time/d, and continuous oral administration for 10 days, Letrozol tablets began to take on the fifth day of menses, 2.5 mg/time, 1 time/d, and continuous oral administration for 5 days.The observation group on the basis of the control group treatment, invigorating kidney for regulating menstruation recipe treatment began to take on the fifth day of menses, daily 1 agent, water frying to 400 ml, 2 times a day, and continuous oral administration for 15 days as a cycle of medication, 2 groups of patients were treated for 3 courses of treatment.Measurement of two groups before and after treatment in patients with serum luteinizing hormone(LH), follicle stimulation hormone(FSH), LH/FSH ratio, serum testosterone(T), estuarial(E2), and fasting, meal after 1 and 2 h insulin(INS) levels, and then compared the two groups of patients with follicular maturation rate, the ovulation rate, pregnancy rate and abortion rate. Results The LH(t=9.763, P=0.003), serum T(t=1.906, P=0.023), LH/FSH(t=3.098, P=0.026) and fasting insulin(t=5.973, P=0.004), postprandial 1H insulin(t=17.009, P=0.000), 2 h pancreatic island prime(t=20.313, P=0.000) levels of observation group were significantly lower than that of the control group after administration of treatment, while E2(t=121.1, P=0.924), FSH(t=0.879, 928) levels of two groups before and after treatment did not change significantly, there was no statistical significance difference.Mature follicles rate, ovulation rate and pregnancy rate of observation group were obviously higher than that of the control group(75.1% vs.46.9%, 89.4% vs.68.5%, 86.6% vs.42.3%, χ2=10.635, 8.428, 9.372; P=0.000), while the abortion rate was significantly lower than that of the control group(10.2% vs.20.3%, χ2=11.744, P=0.002). Conclusion The recipe of invigorating kidney for regulating menstruation combined with leptosome in the treatment of polycystic ovary syndrome ovulation has definite curative effect, it is worthy of promotion. Key words: Recipe of invigorating kidney for regulating menstruation; Leptosome; Polycystic ovary syndrome; Endocrine