Clinical neuropathology features of focal cortical dysplasia type IIb

Abstract

Objective To explore the clinicopathologic features, diagnosis and differential diagnosis methods of focal cortical dysplasia (FCD)Ⅱb. Methods The clinical and pathologic findings of 8 FCDⅡb patients were examined by the gross, microscopic and immunohistochemical methods. Results All the cases were drug-resistant epilepsy patients with the onset in childhood. Most of the patients with epilepsy semiology were the complex partial seizure. Histology features included cortical disorganization, dyslamination, blurred grey and white matter boundary, mouse anti-nonphosphorylated neuronfilament H positive dysmorphic neurons and balloon cells. The balloon cells were enlarged cells with opalescent glassy eosinophilic cytoplasm and with mostly immunohistochemical staining as vimentin, nestin (+ ) and neun, glial fibrillary acidic protein (-). Conclusion Comprehensive analyses of clinical, radiological, microscopic and immunohistochemical findings were important to the accurate diagnosis of FCDⅡb and the critical preoperative localization was crucial for the better prognosis. Key words: Epilepsy; Malformation of cortical development; Biopsy; Balloon cells