Abstract
A compact clinical prototype multi-functional optical coherence tomography (OCT) device for the posterior human eye has been developed. This compact Jones-matrix OCT (JM-OCT) device integrates all components into a single package. Multiple image functions, i.e., scattering intensity, OCT angiography, and the degree of polarization uniformity, are obtained. The device has the capability for measuring local birefringence. Multi-functional imaging of several eyes with age-related macular degeneration is demonstrated. The compact JM-OCT device will be useful for the in vivo non-invasive investigation of abnormal tissues.
Highlights
Optical coherence tomography (OCT) [1] is a non-invasive biomedical imaging modality that can provide high-contrast cross-sectional and volumetric images
The clinical utility of OCT angiography (OCTA) was investigated in several diseases including age-related macular degeneration (AMD) [11], diabetic retinopathy [12,13], and glaucoma [14]
As the clinical utility of OCTA has become widely accepted in ophthalmology, OCTA functionality has been integrated into state-of-the-art commercial OCT devices
Summary
Optical coherence tomography (OCT) [1] is a non-invasive biomedical imaging modality that can provide high-contrast cross-sectional and volumetric images. Local birefringence imaging of the posterior part of the eye was demonstrated with both normal and pathologic subjects In addition to this fully functional JM-OCT device, a simplified clinical-grade multi-functional OCT device was developed [41]. We further develop a clinical JM-OCT device that provides multiple image functions including conventional scattering intensity, OCTA, DOPU, and birefringence. The clinical-grade JM-OCT device was developed by integrating the system components of sweptsource OCT and additional components for Jones matrix measurements in a retinal scanning unit. This developed device achieves a compact footprint by employing encapsulated optical modules. The clinical utility of the developed JM-OCT device is demonstrated by measuring pathologic subjects
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