Clinical-morphological features of malignant ovarian tumors in children in the Republic of Tajikistan

Abstract

Aim. The study of anamnestic and clinical-morphological features of the malignant ovarian tumors (MOT) course in children.Material and methods. Clinical and anamnestic features of 47 cases of MOT in children who received special treatment in the Department of pediatric oncology of the SI “Republican Oncological Scientific Center” for 2005- 2018 were compared. To identify clinical morphological features patients were divided into two groups according to histotypes “teratoblastoma” (17 patients) and “dysgerminoma” (25 patients). The study used anamnestic, physical, clinical-laboratory, sonography, morphological, statistical methods.Results and discussion. As a result of the study, it was found that the main complaints at admission were pain and palpable formation in the abdomen, which had dimensions of up to 10 cm in 19 (40.4%) cases, and in 28 (59.6%) cases - more than 10 cm. Ultrasound examination revealed a tumor-like formation of a heterogeneous/cystic structure, with dense walls, multiple chambers, with inclusions, tuberous, reaching significant sizes of 40-400 mm. The average values of the AFP onco-marker were 155 U/ml, Ca-125 - 87 U/ml, which exceeded the reference values. Dysgerminoma was found in more than half of cases - 25 (53.2%). There were no statistically significant differences in clinical and anamnestic measures between the different histological variants.Conclusion. Comparative analysis of peculiarities of the clinical-morphological course of MOT in children depending on histological type showed no statistically significant differences.