Abstract
Background. The article presents the results of our study aimed to identify predictors of metastatic regional lymph node involvement based on the biological characteristics of the primary tumor. Materials and methods . The study involved 200 female patients with histologically verified unicentric invasive breast cancer (BC) T1-4N0-3M0 who were treated in the state healthcare institution Regional Clinical Cancer Center of Ulyanovsk between 2012 and 2015. Clinical, morphological and molecular parameters of the tumor were analyzed. Results. A unifactorial statistical analysis has shown that the size of the primary tumor node (p = 0.027), histological variant (p < 0.001), malignancy grade (p = 0.027), total malignancy score (TMS, p < 0.001), lymphovascular invasion status (p < 0.001), and HER2-status (p = 0.0002) are predictors of metastatic lymph node involvement. No significant relationship was found between age (p = 0.118), estrogen receptor status (ER, p = 0.092), progesterone receptor status (PR, p = 0.081), Ki-67 index (p = 0.132), molecular subtype of the tumor (p = 0.213) and presence of axillary lymph node metastases. Conclusion. The primary tumor size, histological variant, malignancy grade, TMS, lymphovascular invasion, and HER2-status are independent risk factors of metastatic involvement of regional lymph nodes and may be used by clinicians for axillary surgery planning in BC patients.
Highlights
The article presents the results of our study aimed to identify predictors of metastatic regional lymph node involvement based on the biological characteristics of the primary tumor
The study involved 200 female patients with histologically verified unicentric invasive breast cancer (BC) T1-4N0-3M0 who were treated in the state healthcare institution Regional Clinical Cancer Center of Ulyanovsk between 2012 and 2015
A unifactorial statistical analysis has shown that the size of the primary tumor node (p = 0.027), histological variant (p < 0.001), malignancy grade (p = 0.027), total malignancy score (TMS, p < 0.001), lymphovascular invasion status (p < 0.001), and HER2‐status (p = 0.0002) are predictors of metastatic lymph node involvement
Summary
Клинико-морфологические и молекулярно-биологические предикторы метастатического поражения регионарных лимфатических узлов у больных раком молочной железы. В данной статье изложены результаты собственного исследования, целью которого стал поиск предикторов метастатического поражения регионарных лимфатических узлов на основании биологических характеристик первичной опухоли. В исследование были включены 200 пациенток с морфологически верифицированным уницентричным инвазивным раком молочной железы (РМЖ) Т1-4N0-3M0, пролеченных в ГУЗ «Областной клинический онкологический диспансер» г. По данным однофакторного статистического анализа было выявлено, что размер первичного опухолевого узла (р=0,027), гистологический вариант (р
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