Clinical-microbiological parallels of purulent-septic diseases in children

Abstract

In recent years, purulent-septic diseases in children have become less common, but the widespread pathology and its severe course determine its high relevance. P urpose of the study. Аnalysis of modern clinical and microbiological patterns of purulent-septic diseases in children in order to optimize therapeutic and diagnostic measures. Materials and methods. The authors investigated 2 groups of patients: 2155 children with destructive pneumonia, common appendicular peritonitis and acute hematogenous osteomyelitis treated in three clinics of pediatric surgery of the Russian Federation in 1995–2004, and 1182 patients with the same diseases treated in 2005–2014. Results. It was found out that these PSD began to occur in the second period by 46,2% less than in the first; the greatest decrease in the number of patients is characteristic of destructive pneumonia (-53,7%) and acute hematogenous osteomyelitis (-47,8%). Conclusion . The authors explain the current situation by changing the microbiological spectra of the pathogens of the PSD in children over time. These factors also affect the current characteristics of the syndrome of endogenous intoxication. Using correlation analysis, it was found that the size of a resuscitation bed-day did not correlate with the leukocyte index of intoxication upon admission, but was directly dependent on the level of middle oligopeptides, which the authors recommend to determine in dynamics.