Clinical masks of Non-Hodgkin's lymphoma (clinical case)

Abstract

Clinical polymorphism of non-Hodgkin's lymphoma causes difficulties in early diagnosis. Particular difficulties arise when a patient with lymphoma has specific organ lesions. The article presents a clinical case of non-Hodgkin's lymphoma in a 66-year-old woman hospitalized in the gastroenterology department with symptoms of hepatocellular insufficiency, cytolysis, cholestasis, and hepatosplenomegaly. Patient had a history of thrombocytopenia during 4 years. At the time of this hospitalization viral, toxic and autoimmune causes of liver damage were excluded. The presence of thrombocytopenia, lymphadenopathy of intrathoracic lymph nodes, hepatosplenomegaly allowed to suspect the presence of lymphoproliferative disease. Despite ongoing symptomatic therapy, the patient died. Autopsy confirmed the presence of non-Hodgkin's lymphoma with specific infiltration of multiple internal organs: liver, spleen, kidneys, adrenal glands, myocardium, and valvular apparatus of the heart. Affection of the heart, as a rare manifestation of non-Hodgkin's lymphoma, imitated in our clinical case the sonographic picture of myxoma.