Abstract
BackgroundThe pathology report of radical prostatectomy specimens plays an important role in clinical decisions and the prognostic evaluation in Prostate Cancer (PCa). The anatomical schema is a helpful tool to document PCa extension for clinical and research purposes. To achieve electronic documentation and analysis, an appropriate documentation model for anatomical schemas is needed. For this purpose we developed cMDX.MethodsThe document architecture of cMDX was designed according to Open Packaging Conventions by separating the whole data into template data and patient data. Analogue custom XML elements were considered to harmonize the graphical representation (e.g. tumour extension) with the textual data (e.g. histological patterns). The graphical documentation was based on the four-layer visualization model that forms the interaction between different custom XML elements. Sensible personal data were encrypted with a 256-bit cryptographic algorithm to avoid misuse. In order to assess the clinical value, we retrospectively analysed the tumour extension in 255 patients after radical prostatectomy.ResultsThe pathology report with cMDX can represent pathological findings of the prostate in schematic styles. Such reports can be integrated into the hospital information system. "cMDX" documents can be converted into different data formats like text, graphics and PDF. Supplementary tools like cMDX Editor and an analyser tool were implemented. The graphical analysis of 255 prostatectomy specimens showed that PCa were mostly localized in the peripheral zone (Mean: 73% ± 25). 54% of PCa showed a multifocal growth pattern.ConclusionscMDX can be used for routine histopathological reporting of radical prostatectomy specimens and provide data for scientific analysis.
Highlights
The pathology report of radical prostatectomy specimens plays an important role in clinical decisions and the prognostic evaluation in Prostate Cancer (PCa)
There is no established electronic standard for graphical documentation of PCa that meets clinical and research requirements. These requirements include a flexible documentation of PCa extension with an anatomical schema that can be used for clinical and research purposes
To provide an analyzable data acquisition model for anatomical schemas in electronic form, we propose a document architecture called “clinical Map Document based on XML”
Summary
The pathology report of radical prostatectomy specimens plays an important role in clinical decisions and the prognostic evaluation in Prostate Cancer (PCa). The anatomical schema is a helpful tool to document PCa extension for clinical and research purposes. To achieve electronic documentation and analysis, an appropriate documentation model for anatomical schemas is needed. There is no established electronic standard for graphical documentation of PCa that meets clinical and research requirements. These requirements include a flexible documentation of PCa extension with an anatomical schema that can be used for clinical and research purposes. It is intended to improve information consistency and data integrity of routine data in hospital information systems and clinical studies
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