CLINICAL MANIFESTATIONS, SUBCLINICAL HARACTERISTICS AND COMPLICATIONS OF MEASLES IN PREGNANT WOMEN: A RETROSPECTIVE STUDY IN VIET NAM

Abstract

Measles outbreaks still represents a serious public health problem in developingcountries. There are few reports of measles in pregnant women in the contemporaryliterature. The study aimed to describe clinical features subclinical findings andcomplications of hospitalized measles pregnancy women in Vietnam, in comparisonwith non-pregnancy women.All pregnant women hospitalized with measles at the National Hospital forTropical Diseases, Ha Noi, Northern Vietnam from July 2015 to June 2020 wereincluded. Demographic, clinical manifestations, laboratory findings, andcomplications data were analyzed.Of 98 hospitalized women, the mean time before the rash eruption and that ofsymptoms before hospital admission in the group of pregnant women were 3.5 and4.0 days, which were lower than those of the non-pregnant women group with 4.1and 4.8 days (p = 0.009 and p = 0.004, respectively). Measles rash in the pregnantwomen group was higher than that of the non-pregnant group with (87.8% vs.81.6%; p>0.05). The data of Koplic spot in pregnant women with measles was 34.7%and that of cough symptom was 85.7%. Corresponding in non-pregnant femalepatients were 28.6% and 83.7%, respectively (p < 0.05). The mean CRP value in thepregnant group was higher than that of the non-pregnant group (54.1 mg/L versus26.9 mg/L, p < 0.05). The percentage of pregnant women infected with measles withrespiratory complications was higher than that of no-pregnancy women (65.3% vs.44.9%, p = 0.042). The CRP value ≥ 94.5 mg/l was associated with pneumonia inpregnant women infected with measles (p<0.05; OR 31.2, 95% CI: 2.9 – 337.4).Pneumonitis was the most common complication in pregnant women withmeasles when compared to non-pregnant women. The level of CRP in combinationwith other subclinical findings was also a vital marker in predicting complications ofpregnancy with measles disease