Clinical manifestations of reticular pseudodrusen in Korean patients

Abstract

AbstractPurpose To clarify the clinical characteristics of reticular pseudodrusen(RPD) in Korean patients.Methods The study was designed as retrospective, observational, consecutive case series. A total of 255 eyes of 130 patients diagnosed with RPD were evaluated. RPD were diagnosed by characteristic fundus findings, using multimodal imaging tests. Age related macular degeneration(AMD) was determined by the International Classification and Grading System.Results The mean age of the patients was 72.6±9.0 years(range, 43‐92). Most of the RPD patients had the disease in both eyes(97.7%), with a female preponderance(86.2%). All of the 3 patients with unilateral RPD had shown neovascular AMD in the eye without RPD. AMD was found in 183 eyes(71.8%); early AMD in 115 eyes(45.1%), geographic atrophy(GA) in 41 eyes(16.1%), and neovasuclar AMD in 27 eyes(10.6%). The mean age was 73.7±9.2 years(range, 58‐92) in the RPD group and 69.9±11.7 years(range, 43‐90) in the control group repectively, and there was a statistically significant difference between these two groups(p<0.05). Classic choroidal neovascularization (CNV) was found in 13 eyes (48.1%), and occult CNV was found in 14 eyes (51.9%) in the neovascular AMD group.Conclusion Clinical manifestation of RPD in Koreans did not differ significantly from those described in Caucasians. However, our study demonstrated a higher rate of bilaterality, lower prevalence of AMD, and higher prevalence of GA in RPD patients than those previously reported. Ethnical differences may be associated with these findings and further studies are required.