Abstract
In this study all children(<18 years old) with suspicious history of cow’s milk anaphylaxis who had been referred to IAARI(Immunology,Asthma and Allergy Research Institute)during 2005(JAN)—2010(SEP) were considered. A detailed questionnaire was fulfilled for each patient. A specific severity grading for anaphylaxis with five levels was also used. Skin Prick Test(SPT) with allergen extract(cow’s milk) was performed at least 4—6 weeks after patient’s last anaphylaxis attack. Cow’s milk specific IgE and total IgE level were measured by Immunocap system.Patients with clear history and one positive laboratory test and patients with both positive laboratory tests(SPT and cow’s milk specific IgE)were included.
Highlights
Anaphylaxis is a potentially fatal allergic reaction which is rapid in onset
Cow’s milk specific IgE and total IgE level were measured by Immunocap system.Patients with clear history and one positive laboratory test and patients with both positive laboratory tests(SPT and cow’s milk specific IgE)were included
Most common clinical manifestations were in descending order as: Cutaneous98‰(urticaria,periorbital oedema,flushing),Respiratory91.8‰(dyspnea,coughing,wheezing), Gastrointestinal 55.1‰(nausea,vomiting, abdominal pain),Cardiovascular 46.9‰ and Neurologic 46.9‰.Twenty- four patients had positive SPT
Summary
The aim of this study is to describe the clinical features and severity of cow’s milk anaphylaxis in children
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