Clinical Manifestation of Biliary Atresia in Bali

Abstract

Biliary atresia is a rare disease of the liver and bile ducts that occurs in infants. Biliary atresia is a condition in which the absence of a lumen in the extrahepatic biliary tract causes obstruction of bile flow. Symptoms of the disease appear or develop about two to eight weeks after birth. This study aims to describe the clinical manifestations of patients with Biliary Atresia at Sanglah General Hospital, Bali. This cross-sectional study was performed at the Sanglah Hospital Denpasar, Bali. Data was taken from medical record from January 2015 - December 2020. Study population were children who diagnosed as Biliary Atresia. Diagnosis was confirmed by cholangiography and liver biopsy. The study included 30 infants with Biliary Atresia, mostly (70%) were girl. Average age at admission was 3 months. Ninety percent subject had hepatomegaly in physical examination. Acholic stool were found in 80% subject. The average serum levels of conjugated bilirubin were 9.8 mg/dL, alanine aminotransferase (ALT) was 182 u/L, aspartate transaminase (AST) was 324 u/L, gamma-glutamyl transpeptidase (GGT) level was 671 u/L and albumin was 3.8 g/dL. Seventy percent patient showed triangular cord sign in abdominal ultrasonography. Kasai procedure was performed to all those infants. The most common clinical manifestation was icteric, dark urine, acholic stool and hepatomegaly. Triangular cord sign was the most common finding in abdomen ultrasonography.