Clinical Laboratory Predictors of the Outcome of the Acute Period of Atherothrombotic Ischemic Stroke

Abstract

Objectives. To clarify clinical and laboratory predictors of the acute period of atherothrombotic ischemic stroke (ATS). Materials and methods. Clinical symptomatology, the numbers of peripheral blood leukocytes in apoptosis and necrosis, and the state of the intracellular antioxidant system were assessed in 199 patients. Results and discussion. Among the clinical factors with negative influences on the course of the acute period of ATS, the most important were focus size, impairment to consciousness on day 1, initial SBP, and patient’s age (regression parameter R including clinical factors on day 1 was 0.496, p = 0.01, R on day 7 was 0.739, p < 0.0001; R on day 14 was 0.620, p < 0.0001). Mitochondrial dysfunction and mitochondrion-induced apoptosis were found to have direct influences on the course of ATS in the acute period. Direct relationships were found between the severity of ATS and the number of Mito+ cells on days 1 (r = 0.742, p = 0.009) and 7 (r = 0.717; p = 0.002) and between the severity of ATS and the content of ANV+ leukocytes on days 7 (r = 0.595; p = 0.015) and 14 (r = 0.670; p = 0.007), along with a negative correlation between total SOD and Mn-SOD activities of day 7 (r = 0.628; p = 0.010 and r = 0.675; p = 0.008, respectively), which is evidence for the prognostic value of these indicators.