Clinical, Laboratory, Endoscopic and Histological Correlation to Assess Actual Remission in Patients with Ulcerative Colitis

Abstract

Abstract Background Ulcerative colitis (UC) is an idiopathic inflammatory disease of the colon which results in diffuse friability and superficial erosions on the colonic wall associated with bleeding. It is the most common form of inflammatory bowel disease (IBD) worldwide. Objective Evaluate the correlation between clinical remission, laboratory and inflammatory markers, endoscopic and histological remission in patients with ulcerative colitis. Assess to what extent clinical remission affects “treat to target” policy. Patients and Methods The present study was conducted at Internal medicine and Gastroenterology department, Ain Shams University Hospitals on 30 patients who was diagnosed with ulcerative colitis and were on clinical remission for 6 months. Patients were evaluated for laboratory, endoscopic and histological remission. Results There is significant correlation between mayo score and TLC after remission where Pvalue =0.042*, but no correlation was found with ESR, PLT or HB%. Conclusion There was significant improvement in colonoscopic picture of the study group as regard Mayo score after remission. There was significant improvement in laboratory data of the study group as regard Mayo score after remission. There was no correlation between endoscopic and histologic activity after remission. Fecal calprotectin was significantly correlated with both endoscopic and histologic activity.