Abstract
Clinical Investigation of the Pathogenicity of Pasteurella multocida Isolated from Cattle in Egypt Regarding its Effect on Hematological, Biochemical, and Oxidant-Antioxidant Biomarkers as well as Proinflammatory Cytokines and Acute Phase Proteins
Highlights
Pasteurella multocida is a zoonotic Gram-negative bacterium of global distribution associated with economic losses in animal production (Steen et al, 2010)
Oxidant And Antioxidant Parameters Oxidative stress was investigated by measuring serum malondialdehyde (MDA), nitric oxide (NO), reduced glutathione (GSH), superoxide dismutase (SOD), and total antioxidant capacity (TAC)
Hematology Diseased animals exhibited a significant reduction in RBCs, hemoglobin concentration (Hb), packed cell volume (PCV), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), and mean corpuscular hemoglobin concentration (MCHC) values compared with the apparently healthy animals (P
Summary
Pasteurella multocida is a zoonotic Gram-negative bacterium of global distribution associated with economic losses in animal production (Steen et al, 2010) It causes hemorrhagic septicemia, fowl cholera, atrophic rhinitis, and snuffles in bovids, birds, swines, and rabbits, respectively (Moustafa et al, 2015). Several studies have been conducted on P.multocida, there is scarce information about its pathogenicity and its effect on hematological, biochemical, and immunological parameters. To overcome this gap, this work aims to isolate and identify P.multocida from healthy and pneumonic cattle to perform molecular confirmation, capsular typing, detection of virulence genes, and display of antimicrobial susceptibility profiles of the gained isolates. To investigate changes in hematology, biochemistry, biomarkers of oxidative stress, with particular emphasis on the role of proinflammatory cytokines and acute-phase proteins in disease control
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