Abstract
BackgroundPolypoidal choroidal vasculopathy (PCV) is one of the disorders within the pachychoroid spectrum diseases. The presence of pachyvessels is one of the characteristics of pachychoroid disorders. However, the relationship between the presence of pachyvessels and the clinical characteristics of PCV eyes has not been determined. The purpose of this study was to determine the relationship between the presence of choroidal pachyvessels and the clinical characteristics of eyes with PCV.MethodsThe medical records of patients who were diagnosed with PCV and were treatment-naïve were reviewed. Fluorescein and indocyanine green angiography, fundus photography, spectral domain optical coherence tomography (SD-OCT), and enhanced depth imaging OCT (EDI-OCT) were used to obtain images of the choroid. The presence of pathologically dilated outer choroidal vessels, pachyvessels, was determined by ICGA images. These pachyvessels were confirmed to correspond with the large choroidal vessels in the EDI OCT images. The PCV eyes were divided into two groups based on the presence or absence of pachyvessels and clinical features and subfoveal choroidal thickness (SFCT) were evaluated between the two groups.ResultsEighty-six eyes of 84 patients with PCV were evaluated. Pachyvessels were detected in 48 eyes (55.8%). The mean SFCT was 203.9 ± 83.9 μm in all 86 eyes, and it was significantly thinner in eyes with pachyvessels (+) than without pachyvessels (−) (183.2 ± 58.4 μm vs 230.2 ± 103.1 μm; P = 0.01). The differences in the incidence of subretinal fluid, pigment epithelial detachments, and hemorrhages between the two groups were not significant. However, the PCV eyes in pachyvessels (+) group with hemorrhage had the thinnest choroid (P = 0.047). The choroidal features of the fellow eyes were similar to those of the PCV affected eyes, that is, the fellow eyes in pachyvessels (+) group had pachyvessels and the fellow eyes in pachyvessels (−) group did not have pachyvessels.ConclusionsPachyvessels were presented 55.8% in eyes with PCV, and these eyes had the thin SFCT. The presence of pachyvessels and attenuation of the inner choroid were probably due to the pathological changes in the eyes with PCV.
Highlights
Polypoidal choroidal vasculopathy (PCV) is one of the disorders within the pachychoroid spectrum diseases
Polypoidal choroidal vasculopathy (PCV) was first described by Yannuzzi et al [1], and it was considered to be a subtype of neovascular age-related macular degeneration (AMD)
The pachychoroidal spectrum disorders are characterized by alterations to the choroid which may be manifested as increased choroidal thickness, presence of pathologically dilated choroidal vessels in Haller layer, i.e., pachyvessels, and regional choroidal hyperpermeability [3,4,5]
Summary
Polypoidal choroidal vasculopathy (PCV) is one of the disorders within the pachychoroid spectrum diseases. The relationship between the presence of pachyvessels and the clinical characteristics of PCV eyes has not been determined. The purpose of this study was to determine the relationship between the presence of choroidal pachyvessels and the clinical characteristics of eyes with PCV. The pachychoroidal spectrum disorders are characterized by alterations to the choroid which may be manifested as increased choroidal thickness, presence of pathologically dilated choroidal vessels in Haller layer, i.e., pachyvessels, and regional choroidal hyperpermeability [3,4,5]. The pachyvessels are usually associated with a thinning of the overlying choriocapillaris in eyes with PCV [13]. The term pachychoroid was originally coined to reflect a choroidal thickening, subsequently the choroidal thickness was found not to be the most important criterion for defining pachychoroid disorders [14]
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