Abstract
Lung cancer is one of the leading causes of death globally.1 Tobacco smoking causes nearly 90% of lung cancers. The major histologic types of lung cancer include adenocarcinoma, squamous-cell carcinoma, small-cell carcinoma, large-cell neuroendocrine carcinoma, and pulmonary carcinoid tumors.2 Although some molecular alterations are shared among various histologic subtypes, the majority of genomic alterations remain distinct. In this review, we discuss recent studies of large-scale genomic analyses of the three most common histologic types of lung cancer — adenocarcinoma, squamous-cell carcinoma, and small-cell carcinoma — and their implications for the management of this disease. Genomic Alterations The Genomic Landscape Lung . . .
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