Abstract
In the study, we investigated the correlation between EphB4 receptor expression and the angiogenesis of pancreatic cancer. EphB4 receptor is unevenly distributed or distributed with small patches in pancreatic ductal cell cancer. While EphB4 receptor was not expressed in normal pancreatic tissues. It can be observed that the mRNA of EphB4 receptor is high expressed in all 15 cases of pancreatic ductal cell cancer tissues but not expressed in normal pancreatic tissues. Finally, positive correlation was observed between the mRNA expression level of EphB4 receptor and MVD. Immunohistochemical analysis showed that EphB4 receptor protein expression was related to tumor differentiation and clinical stage. It can be observed that MVD is relevant to histological differentiation and clinical stage. EphB4 receptor is correlated to the initiation, progression and tumor angiogenesis. In conclusion, EphB4 receptor maybe a promising targeted goal of antiangiogenic formation, which provides a new approach and method for tumor treatment.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
