Abstract
substance P and A23187 was significantly impaired in PES at NSRS (Pb.05 vs. BMS and naive, respectively). Local O2 − production at both proximal and distal NSRS was elevated for PES compared to BMS and naive arteries (proximal: PES 36±3 vs. BMS 15±2 and naive 12±1, Pb.001; distal: PES 77±4 vs. BMS 23±5 and naive 19±1 RLU/s per milligram of tissue, Pb.001). Conclusions: Abnormal endothelium-dependent relaxation was demonstrated after overlapping PES implantation. Profound localized inflammatory reaction, as well as enhanced local oxidative stress, may contribute to vasomotor dysfunction.
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