Abstract
Objective. Three point mutations (A2143G, A2142G, and A2142C) have been involved in Helicobacter pylori (H. pylori) clarithromycin resistance. No study has assessed the distribution of the different mutations and their role on H. pylori treatment outcome in children. Recently, in adults the sequential therapy proved to be effective even in clarithromycin resistant strains. Aim of our study was to assess the prevalence and distribution of primary clarithromycin resistance in children, their in the success of eradication therapy, and the efficacy of sequential therapy as compared to standard triple therapy against chlarithromycin resistant strains.
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