Abstract
Background: Esophageal Squamous cell carcinoma is the most prevalent type of Esophageal cancer in the world. The presence of Tumour infiltrating lymphocytes indicates a good prognosis of the cancer and this may suggest a good response to immunotherapy. Numerous immunological inhibitors have been developed to treat a variety of cancers; however, the role of Tumour Infiltrating Lymphocytes in Esophageal Squamous Cell Carcinoma has not been substantiated with proper evidence. Methodology: The study enrolled 27 patients of Esophageal Squamous Cell Carcinoma between the years 2014-2019. The evaluation was based on the criteria laid down by the International Tumour Infiltrating Lymphocytes Working Group 2014 and scoring of the same was done in 400x field and were reported. Results: A total of 27 cases were studied, of which 17 were males and 10 were females. The commonest age group was 60-70 years. 22 cases had tumours sized between 3-7cm. Tumour grading of pT1 was seen in 1 case, grading of pT2 in 10 cases and pT3 in 16 cases. Tumour Infiltrating Lymphocytes were scored based on the standard scoring system, and the results showed that 3 cases were of Score 0, 14 cases of Score 1, 4 cases of Score 2, and 6 cases of Score 3. Conclusion: The commonest score of 1 was seen in 51.8% of the cases and that of score 3 was seen in 22.22% of the cases. Tumour Infiltrating Lymphocytes can hence serve as a predictor for good prognosis of Esophageal Squamous Cell Carcinoma following surgery or radiotherapy/chemotherapy.
Published Version
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