Clinical Impact and Predictors of Diffusion Weighted Imaging(DWI) Reversal in Stroke Patients with Diffusion Weighted Imaging Alberta Stroke Program Early CT Score0-5 Treated by Thrombectomy : Diffusion Weighted Imaging Reversal in Large Volume Stroke.

Abstract

To determine whether reversal of DWI lesions (DWIr) on the DWI-ASPECTS (diffusion weighted imaging Alberta Stroke Program CT Score) template should serve as apredictor of 90-day clinical outcome in acute ischemic stroke (AIS) patients with pretreatment diffusion-weighted imaging (DWI)-ASPECTS0-5 treated with thrombectomy, and to determine its predictors in current practice. We analyzed data of all consecutive patients included in the prospective multicenter national Endovascular Treatment in Ischemic Stroke Registry between 1 January 2015 and 31 December 2020 with apremorbid mRS ≤ 2, who presented with apretreatment DWI-ASPECTS 0-5score, underwent thrombectomy and had an available 24 h post-interventional MRI follow-up. Multivariable analyses were performed to evaluate the clinical impact of DWIr on early neurological improvement (ENI), 3‑month modified Rankin scale (mRS) score distribution (shift analysis) and to define independent predictors of DWIr. Early neurological improvement was detected in 82/211 (41.7%) of patients while 3‑month functional independence was achieved by75 (35.5%) patients. The DWI reversal (39/211, 18.9%) resulted an independent predictor of both ENI (aOR3.6, 95% CI 1.2-7.7; p0.018) and 3‑month clinical outcome (aOR for mRS shift:2.2, 95% CI 1-4.6; p0.030). Only successful recanalization (mTICI2c-3) independently predicted DWIr in the studied population (aOR3.3, 95% CI 1.3-7.9; p0.009). The DWI reversal occurs in anon-negligible proportion of DWI-ASPECTS0-5 patients subjected to thrombectomy and significantly influences clinical outcome. The mTICI2c-3 recanalization emerged as an independent DWIr predictor.