Abstract
To the Editor: Protein kinase A regulatory subunit-α (PRKAR1A) is inactivated in a subset of melanocytic neoplasms, including pigmented epithelioid melanocytoma (PEM), melanotic schwannoma (MS), and the exceptionally rare pigmented epithelioid melanoma.1,2 The genomic profiles of PEM and MS have been well described; PEM typically lacks genomic alterations (GAs) in the TERT promoter or CDKN2A gene or significant chromosomal copy number alterations, whereas MS shows monosomies of chromosomes 1, 2, and 17.
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