Abstract
BACKGROUND: Calcium hydroxylapatite (CaHa) is one of many newly available soft tissue fillers.OBJECTIVE: We have, in this pilot study, evaluated the clinical, histologic and electron microscopic ultrastructural changes seen with CaHa at 1 and 6 months after skin injection.METHODS: Each of the three subjects was injected in the postauricular area with 0.1 cc of CaHa gel. A 3‐mm punch tissue biopsy was taken at 1 and 6 months post‐injection. Biopsies were analyzed by histopathology and electron microscopy. Clinical results after injection of the nasolabial folds were also evaluated.RESULTS: CaHa particles were found to persist at 6 months with evidence of new collagen formation being seen. Patients still showed clinical improvement at this time.CONCLUSION: This study is the first in vivo ultrastructural analysis of the biologic response to CaHa in human skin. CaHa shows clinical, histologic and electron microscopic evidence of persistence at 6 months.
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