Abstract
The purpose of this study was to investigate clinical, functional and laboratory features of the ACOS syndrome (asthmaCOPD overlap syndrome).Methods. We examined 108 patients: 54 patients with ACOS syndrome and 54 patients with severe asthma.Results. The ACOS syndrome was characterized by severe course, lower lung function and pulmonary hyperinflation. A high level of systemic inflammatory markers (IL6, TNFα, CRP) was registered in both the groups. An increased neutrophil elastase blood plasma concentration was revealed in patients with the ACOS syndrome that could indicate a role of neutrophils in the inflammation. sCD31/SPECAM1 and CD38 on blood lymphocytes were higher in the ACOS group compared to the asthma group; this could be related to cellular and molecular mechanisms of endothelial dysfunction.Conclusion: The current knowledge on the ACOS syndrome is insufficient. Clinical course and pathogenesis of this disease require further investigation.
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