Abstract
The two common types of neurofibromatosis (NF) are genetically and clinically distinct diseases, each of which promotes the growth of neurofibromas and schwannomas that arise in the myelin nerve sheaths of peripheral or cranial nerves. Other tumors may arise from a variety of tissues including meningiomas, optic gliomas, and ependymomas. Both NF1 (chromosome 17q) and NF2 (chromosome 22q) are dominantly transmitted, with half of cases arising from new mutations. Diagnostic criteria for NF1 and NF2 have been developed by consensus.1 Physical features and neuroimaging of NF are shown in figures 1 and 2 …
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