Clinical findings in the use of Tofranil in depressive and other psychiatric states. 1959.

Abstract

1. Preliminary observation would indicate that Tofrānil is a useful drug in the treatment of depressive states. It is not a tranquilizer and, therefore, is of little value in other conditions. It is a promising drug which can be used as an anti-depressant. However, its indication and scope must be studied for a longer period to determine what symptoms respond best to it. 2. The effect of Tofrānil in many patients can be increased by the concomitant use of a tranquilizer or a stimulant. In a number of patients Tofrānil, by removing the depressive elements, frees and exaggerates anxiety. 3. It can be used in combination with electric shock or after electric shock as a maintenance dose. 4. It is of little value in the treatment of schizophrenics and in paranoid types may often aggravate the condition and break down an unstable equilibrium to which the patient has become adjusted. 5. The combined use of Tofrānil and a tranquilizer is helpful in certain psychoneurotic states, associated with anxiety or with re...