Abstract
BackgroundAn increased number of congenital Zika virus infections with neurological and musculoskeletal malformations have been diagnosed worldwide, however, there are still several gaps in the knowledge about this infection, its associated mechanism, timing of transmission, and description of throughout findings of signs and symptoms, which is described in this paper. The purpose of this study is to describe aspects of congenital Zika syndrome (CZS) beyond the central nervous system comprising detailed delineation of all the other clinical findings.MethodsA retrospective research developed using electronic medical records. We analyzed the files of 69 children with an initial diagnosis of microcephaly by Zika vírus who were born in 2015, 2016 and 2017, treated during the period from 2016 to 2017.ResultsThe newborns presented several neurological and musculoskeletal malformations, eye damage, hearing impairment and other malformations.ConclusionsThe present study has significant impact for health care teams following lactents with Congenital Zika Syndrome.
Highlights
Zika virus (ZIKV) is an Arbovírus, belonging to the genera Flavivirus (Flaviviridadae family) which is transmitted primarily via Aedes aegypti
In 2015, The World Health Organization (WHO) recognized that Zika virus was responsible for microcephaly and related neurologic disorders in infants born from infected mothers [1]
Diagnostic criteria for Zika virus infection were performed by serology (IgM, IgG), and molecular tests (PCR +); and neuroimaging examinations (MRI and CT) of infants that confirmed the pattern of sequelae of ZIKV infection
Summary
Zika virus (ZIKV) is an Arbovírus, belonging to the genera Flavivirus (Flaviviridadae family) which is transmitted primarily via Aedes aegypti. In 2015, The World Health Organization (WHO) recognized that Zika virus was responsible for microcephaly and related neurologic disorders in infants born from infected mothers [1]. An increased number of congenital Zika virus infections with neurological and musculoskeletal malformations have been diagnosed worldwide, there are still several gaps in the knowledge about this infection, its associated mechanism, timing of transmission, and description of throughout findings of signs and symptoms, which is described in this paper. The purpose of this study is to describe aspects of congenital Zika syndrome (CZS) beyond the central nervous system comprising detailed delineation of all the other clinical findings
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