Abstract

Objective To investigate clinical characteristics, quality of life, and psychological fac- tors in functional dyspepsia (FD) patients with weight loss. Methods A multi-center and prospective investigation was conducted (Clinical trial registration number: ChiCTR-TRC-12001968 ) which recruited 1341 consecutive FD outpatients from three Guangdong hospitals according to Rome In criteria between June and September in 2012. Of these, 1057 patients with complete information were divided into group A as having weight loss more than 5% (n =207) and group B as having weight loss less than 5% (n =850). Nepean Dyspepsia Index-symptom checklist, appetite, Hamilton Rating Scale of Anxiety/Depression (HAMA/ HAMD), Pittsburgh Sleep Quality Index (PSQI), Nepean Dyspepsia Index-quality of life, direct medical costs were used to compare the differences between the two groups. Results There were no significant differences in total scores of NDI-symptom checklist, the severity or bothersome items between two groups (t = - 1. 301, -0. 918,0. 138,P =0. 193,0. 359,0. 890), but significant differences were observed in the frequence item and the rating of appetite as poor or very poor between two groups ( t = - 2. 122 ,P = 0. 035 ;X2 =35. 448,P =0. 000;X2 =35. 274,P =0. 000). Significant differences were observed in the incidence of anxiety and depression and total scores of PSQI between the two groups (X2 = 73. 939, P = 0. 000 ;X2 = 47. 046, P = O. 000 ; t = - 4. 904, P = 0. 000). Subscales scores of NDI-quality of life in group B were all sig- nificantly higher than those in group A (t = 5. 348,2. 569,5. 809,4. 704, P = 0. 000,0. 010,0. 000,0. 000 ). There were significant differences in the frequency of care-seeking and direct medical costs between the two groups (t = -4. 860, -3.011, P = 0. 000,0. 003 ). The frequency of gastroseopic examinations in group A was slightly higher than that in group B ( t = - 1. 505,P = 0. 133 ). Conclusion FD patients with weight loss is not rare, and most of them have psychological disorders, loss of appetite and sleep disturbance. More- over, care-seeking are more frequent, direct medical costs are more expensive, and impairment as assessed by NDI-QOL is more severe. Therefore, we should pay more attention to FD with weight loss in clinical setting. Key words: Dyspepsia; Quality of life ; Anxiety; Depression

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