Clinical features of the organ damage in early-onset preeclampsia and their association with prenatal outcomes: comparison on Uigur and Kazak patients in Xinjiang

Abstract

Objective To analyze association between organ damage and pregnancy outcome of early-onset preeclampsia (E-PE) patients, who were Uigur or Kazak in Xinjiang. Methods This retrospective study of 297 E-PE pregnant women including 145 Uigur and 152 Kazak patients from Jan. 2009 to Dec. 2010 in Yili State Youyi Hospital was done. The clinical data were recorded and comparisons on organ damage and pregnancy outcome were analyzed. We used t test to compare the quantitative data, Chi-Square test to compare qualitative data. Results The study revealed that patients were mainly with one organ damage. Patients with placenta or renal damage were the most common in Uigur (26/61, 42.6% and 17/61, 27.9%, respectively), while patients with placenta, heart or brain damage were most common in Kazak (24/65, 37.1%, 15/65, 23.1% and 12/65, 18.5%, respectively). If patients with two organs damage, Uigur patients were primarily with placenta and renal damage(15/24, 62.5%), Kazak patients were most common with placenta damage and eclampsia (9/25, 36.0%) or brain damage (12/25, 48.0%). The perinatal mortality showd no significant difference in Uigur and Kazak groups [44.4%(40/90) vs 46.9%(46/98), χ2=0.118, P>0.05]. Conclusions It shows significant difference of organ damage in early-onset preeclampsia patients who are Uigur and Kazak nationality. But the perinatal mortality shows no significant difference between the two groups. Key words: Preeclampsia; Minority health; Pregnancy complications