Abstract
Aim: The aim of this study was to evaluate the clinicopathological features and prognosis of gastric Signet Ring Cell Carcinoma (SRCC) including measurement of tumor markers (CEA, CA 19-9) and CRP. Material and method: There were 19 patients with histopathological diagnosis of signet ring cell carcinoma of the stomach. Clinicopathological parameters, including gender and age of the patients, duration of symptoms, size and location of tumors, depth of invasion (T stage), lymph node metastasis status (N stage), distant metastasis (M status) and operative details, were collected retrospectively. CEA, CA 19-9 and CRP levels were measured in all patients. Results: The mean age of the patients was 63.74 ± 15.07 (range 37-90 years). Median survival time was 17.4 ± 10.7 month (range 4-48 months). The mean CA 19-9 level was 14.4 ± 23.1 (0.8-101.6), CEA level was 91.9 ± 227.2 (0.46-989) and CRP level was 1.79 ± 1.19 (0.3-3.7). Sixteen patients were classified as stage III or IV disease. Five patients were operated with total gastrectomy and 9 patients with gastroenterostomy due to unresectable tumor. Conclusion: Clinicopathological behavior of gastric SRCC is still debated. In this serial, most of the patients with gastric SRCC were diagnosed and treated in last stages of their diseases. Although CA 19-9 and CEA levels were inceased in some patients with SRCC, diagnostic value of these markers is debated.Another marker CRP was found normal in most of the patients with gastric SRCC in this serial.
Highlights
Gastric carcinoma shows declining incidence in last years, it is one of the gastrointestinal cancer with high morbidity and mortality
Five patients were operated with total gastrectomy and 9 patients with gastroenterostomy due to unresectable tumor
CA 19-9 and Carcinoembryonic antigen (CEA) levels were inceased in some patients with signet ring cell carcinoma (SRCC), diagnostic value of these markers is debated.Another marker C-reactive protein (CRP) was found normal in most of the patients with gastric SRCC in this serial
Summary
Gastric carcinoma shows declining incidence in last years, it is one of the gastrointestinal cancer with high morbidity and mortality. World Health Organization (WHO) was classified the gastric adenocarcinoma into four predominant histological types. These are tubular adenocarcinoma, papillary adenocarcinoma, mucinous adenocarcinoma (MAC) and signet ring cell carcinoma (SRCC) [1]. SRCC is a descriptive term used for a specific type of mucin-producing adenocarcinoma. Intracytoplasmic mucin pushes the nuclei one side of cell and cause the typical appreance of signet ring in these tumor cells. 95 % of SRCC originates from stomach. It can be arised from colon, breast, gallbladder and pancreas [2]. The clinicopathological characteristics and prognosis in patients with SRCC of the stomach are still controversial. Some studies reported that early-stage gastric SRCC was associated with a better prognosis than non-SRCC, others claimed that SRCC had a prognosis similar to nonSRCC [3,4,5,6,7,8]
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