Abstract
Intra-tumour haematoma is an uncommon clinical presentation in malignant soft tissue tumours. This study aimed to highlight the clinical features of patients with soft tissue sarcomas with intra-tumour haematoma. The patient group was composed of eight men and one woman aged between 29 and 83years (mean 44.0 ± 20.8). The average follow-up was 29.8months. Clinical information, including clinical features, radiological information and treatment course, was retrospectively investigated. Tumours were predominantly located in the chest wall and thigh, and average diameter was 10.3cm. Six patients underwent needle biopsy with ultrasound sonography, and three underwent an open biopsy. Histological diagnoses indicated that all tumours were high grade, three of which were undifferentiated pleomorphic sarcomas, three synovial sarcomas, two pleomorphic liposarcomas, one a leiomyosarcoma and one a malignant peripheral nerve sheath tumour. The median diagnostic delay time was 3.0months. Magnetic resonance imaging (MRI) indicated a haematoma area <25% in three, 25-50% in four and 50% two. A wide resection was performed in eight patients, and radiotherapy was administered to one patient for the initial local treatment of a primary tumour. Local recurrence was detected in four patients, whilst five developed lung metastases. The five-year survival rate was 57.1% and median survival 34.0months. Soft tissue sarcomas with intra-tumour haematoma presented with locally aggressive and highly metastatic behavior, consistent with high-grade tumours.
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