Clinical features of primary open-angle glaucoma in patients with hereditary tainted family history

Abstract

This review describes currently most well-known research findings dedicated to the specific features of manifestation and course of primary open-angle glaucoma with hereditary tainted history. Despite the fact that aggravated heredity has been confirmed as a risk factor for primary open-angle glaucoma (POAG), the information on the clinical features and progression patterns of POAG in patients with hereditary predisposition presented in the existing publications is scattered, and its availability is still limited by the amount of included material. All of this, in turn, makes it impossible to fully predict the course of the disease and to discuss the possibility of its earlier detection in that population group. The discussion presented in this work points out the type of kinship for which the risk of developing glaucoma is most relevant, as well as the supposed characteristics of the age of onset of POAG among patients with a family history of this disease. The results of the studies analyzed in this review can help actualize the viewpoint on the possible differences in clinical manifestations of the disease in patients with hereditary (familial) and sporadic forms of glaucoma, as well as on the necessity of further clinical research in this area.