Clinical features of primary multiple eyelid basal cell carcinoma

Abstract

Aim. Identification of clinical and epidemiological features of primary multiple eyelid basal cell carcinoma. Methods. 53 patients with multiple eyelid basal cell carcinoma were included in the main group, the control group included 98 patients with solitary forms of eyelid basal cell carcinoma, who were not diagnosed with primary multiple lesions during 7 years of follow-up. Diagnosis of a malignant disease of the eye was based on the disease history, complex ophthalmic clinical and instrumental examinations, the diagnosis of multiple eyelid basal cell carcinoma was verified by cytological and histological examination. Magnetic resonance imaging and computed tomography of the orbit, brain, abdominal cavity were used to assess the area of malignancy. Results. Primary multiple eyelid basal cell carcinoma was diagnosed mainly in elderly patients over 70 years old (58.49% of patients), whereas a solitary basal cell carcinoma was significantly more common in patients of the younger age group - from 30 to 59 years old (24.49% of patients). Neoplastic process in primary multiple eyelid basal cell carcinoma was mainly localized on the skin of the outer canthus (13.20%), presenting mainly as nodular form (64.15%), with differentiated tumor dominating morphologically. Primary multiple eyelid basal cell carcinoma is diagnosed in 1.64% of patients with tumors of organ of vision, with two metachronous tumors in most of the cases (69.81%), associated with skin epithelial malignant tumors, breast, uterine, kidney and rectal cancer. Conclusion. The clinical features of primary multiple eyelid basal cell carcinoma are the following: age of 70 years and over, verification at T1N0M0 cancer stage, predominantly nodular form (64.15%), with differentiated tumor dominating morphologically.