Abstract
Purpose To clarify the clinical features of patients with exfoliation glaucoma (XFG) requiring surgical intervention. Study Design. Retrospective study. Methods The study included 46 eyes from 36 XFG patients, 85 eyes from 53 primary open-angle glaucoma (POAG) patients, and 54 eyes from 35 normal-tension glaucoma (NTG) patients. Age, duration of previous glaucoma treatment, intraocular pressure, medication scores, visual function, and surgical procedure were compared among the three patient groups. Results The XFG group had the highest mean age (XFG: 75.7 ± 8.3 years, POAG: 65.8 ± 12.8 years, and NTG: 53.3 ± 12.8 years; p < 0.001) and the shortest mean duration of previous treatment with glaucoma medication (XFG: 5.1 ± 3.5 years, POAG: 8.9 ± 6.9 years, and NTG: 8.9 ± 5.9 years; p < 0.001). Intraocular pressure and medication scores were slightly higher in the XFG group than in the POAG group, although the differences were not significant. Among XFG patients, trabeculectomy was performed in 20 eyes from 16 patients (55.6%) and trabeculotomy was performed in 16 eyes from 14 patients (44.4%). Both trabeculectomy (3 eyes) and trabeculotomy (14 eyes) were performed in combination with cataract surgery. Conclusions The XFG patients referred to our department for initial examination were older than the POAG and NTG patients, and their duration of treatment before referral was shorter. Moreover, intraocular pressure and the eye drop medication score were higher in the XFG patients. A significantly higher percentage of XFG patients required surgical intervention compared to patients with other disease types.
Highlights
Exfoliation glaucoma (XFG) is a secondary open-angle glaucoma that occurs in one or both eyes, mainly among the elderly. is secondary glaucoma is most prevalent in patients aged â„70 years, and it is the most frequent open-angle glaucoma associated with high intraocular pressure (IOP) in this age group [1,2,3,4]
In clinical research in the United States and Europe, XFG, such as primary open-angle glaucoma (POAG) and normal-tension glaucoma (NTG), is often treated as open-angle glaucoma [6, 7]. us, drugs are initially administered, while surgical treatment is considered if adjustment of IOP is difficult or if there is progressive visual field impairment [8]. e clinical features of XFG patients differ from those of POAG and NTG patients; XFG patients are older at diagnosis, have more severe visual field constriction, have higher IOP, and exhibit greater variability [9,10,11,12,13,14,15,16]
There were 46 eyes from 36 XFG patients, 85 eyes from POAG patients, and eyes from 35 NTG patients. e following details are provided in Table 1: age at the initial visit to our institution, sex, duration of treatment, IOP value, eye drop instillation score, and visual field score (MD and visual field index (VFI) values)
Summary
Clinical Features of Patients with Exfoliation Glaucoma Requiring Surgical Intervention. To clarify the clinical features of patients with exfoliation glaucoma (XFG) requiring surgical intervention. E study included 46 eyes from 36 XFG patients, 85 eyes from primary open-angle glaucoma (POAG) patients, and eyes from 35 normal-tension glaucoma (NTG) patients. Duration of previous glaucoma treatment, intraocular pressure, medication scores, visual function, and surgical procedure were compared among the three patient groups. Intraocular pressure and medication scores were slightly higher in the XFG group than in the POAG group, the differences were not significant. Intraocular pressure and the eye drop medication score were higher in the XFG patients. A significantly higher percentage of XFG patients required surgical intervention compared to patients with other disease types
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