Abstract
Basedow Graves disease (BGD) is the leading cause of hyperthyroidism. The characteristics of patients seen at a university hospital may differ from those described in the general population. To describe the clinical features of patients with BGD seen at a university hospital. Review of medical records of all patients seen at our hospital between 2009 and 2014 with the diagnosis of thyrotoxicosis, hyperthyroidism or BGD. Clinical features, laboratory results and treatments were recorded. We reviewed clinical records of 272 patients; 15 had to be excluded due to incomplete data. BGD was present in 77.9% (n = 212). The mean age of the latter was 42 years (range 10-81) and 76% were women. Ninety six percent were hyperthyroid at diagnosis and thyroid stimulating hormone was below 0.1 mIU/L in all patients. Median free thyroxin and triiodothyronine levels were 3.26 ng/dl and 3.16 ng/ml, respectively. Thyrotropin-receptor antibodies were positive in 98.5% and 85.7% had positive thyroid peroxidase antibodies. Graves orbitopathy (GO) was clinically present in 55% of patients. Of this group, 47% had an active GO, 26% had a moderate to severe disease and 7.8% had sight-threatening GO. As treatment, 26% received radioiodine, 44% anti-thyroid drugs exclusively, 28% underwent thyroidectomy and 2% did not require therapy. In this group of patients, we observed a greater frequency of severe eye disease and a high rate of surgical management. This finding could be explained by referral to highly qualified surgical and ophthalmological teams.
Highlights
Recibido el 13 de septiembre de 2016, aceptado el 4 de abril de Correspondencia a: Dra
Clinical features of patients with Basedow Graves disease seen at a university hospital Background: Basedow Graves disease (BGD) is the leading cause of hyperthyroidism
Aim: To describe the clinical features of patients with BGD seen at a university hospital
Summary
Recibido el 13 de septiembre de 2016, aceptado el 4 de abril de Correspondencia a: Dra. Clinical features of patients with Basedow Graves disease seen at a university hospital Background: Basedow Graves disease (BGD) is the leading cause of hyperthyroidism. Aim: To describe the clinical features of patients with BGD seen at a university hospital. Material and Methods: Review of medical records of all patients seen at our hospital between 2009 and 2014 with the diagnosis of thyrotoxicosis, hyperthyroidism or BGD. Graves orbitopathy (GO) was clinically present in 55% of patients Of this group, 47% had an active GO, 26% had a moderate to severe disease and 7.8% had sight-threatening GO. Conclusions: In this group of patients, we observed a greater frequency of severe eye disease and a high rate of surgical management. Las alternativas terapéuticas más utilizadas son los fármacos antitiroideos (FAT) y el tratamiento con radioyodo, reservándose la cirugía para casos específicos[4]. El objetivo de este estudio es caracterizar a los pacientes que se controlan por EBG en un centro donde se cuenta con un equipo multidisciplinario especializado para el manejo de esta patología
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