Abstract
Investigators from University of Oxford, Birmingham Children's Hospital, Guy's and St Thomas', London, UK, performed a prospective surveillance study in children with NMDAR-Ab-mediated neurological disease reported from Nov 2010 to Dec 2011.
Highlights
Anti-NMDAR Abs in CSF is the diagnostic marker for NMDAR encephalitis, and the diagnosis may be supported by the EEG pattern “extreme delta brush.”[2]
This pattern named because of its resemblance to the EEG of premature infants is reported in 30% of adult patients with NMDAR encephalitis
In pediatric patients with behavioral disorders and abnormal movements, early EEG patterns may be suggestive of anti-NMDAR encephalitis
Summary
Pediatric NMDAR-Ab encephalitis often presents with neurological rather than psychiatric symptoms, the more common presentation in adults with the disease. Patients diagnosed and treated early with immunotherapy have a better prognosis than those treated late [1].
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