Abstract
The prevalence of myasthenia gravis is 10-24 cases per 100, 000 population. The debut of the disease is possible at any age: from infancy to old age. In the literature, the definition of “myasthenia gravis with late onset” – at the age of 60 years and older, which is 20-46% of all cases. In this regard, the disease is often combined with a burdened somatic history, which makes it difficult to timely diagnosis and treatment. This group of elderly patients accounts for the majority of diagnostic errors in the diagnosis of myasthenia gravis. This study is devoted to the study of the features of the onset and course of myasthenia gravis in elderly and senile people.
Highlights
Myasthenia gravis is a chronic autoimmune neuromuscular disease [1]
In 75% of cases, the disease debuts at the age of 15 to 30 years [1-3], but in the literature of recent years, the definition of "myasthenia gravis with a late onset" - at the age of 60 years and older, which is 20-46% of all cases [4]
Myasthenia gravis with late onset is characterized by a combination with chronic somatic pathology, which makes timely diagnosis and treatment difficult [8-10]
Summary
Myasthenia gravis is a chronic autoimmune neuromuscular disease [1]. The disease is clinically characterized by weakness and pathological muscle fatigue due to the formation of autoantibodies to various antigenic structures of the neuromuscular synapse [2,3].The prevalence of myasthenia gravis is 10-24 cases per 100,000 population. Myasthenia gravis is a chronic autoimmune neuromuscular disease [1]. In 75% of cases, the disease debuts at the age of 15 to 30 years [1-3], but in the literature of recent years, the definition of "myasthenia gravis with a late onset" - at the age of 60 years and older, which is 20-46% of all cases [4]. The course of the disease at a young age can often be aggravated by a combination with other autoimmune disorders: pathology of the thyroid gland (hyper- or hypothyroidism), rheumatoid arthritis or diabetes mellitus [6,7]. Myasthenia gravis with late onset is characterized by a combination with chronic somatic pathology, which makes timely diagnosis and treatment difficult [8-10]. The group of elderly patients accounts for the majority of diagnostic errors in the diagnosis of myasthenia gravis
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