Abstract
There is a scarcity of reports addressing patients with multiple primary malignancies (MPM), especially for Chinese cses. The aim of this study was to present a detailed analysis of Chinese patients presenting with at least two primary malignancies. Particularly, the clinical characteristics and survival between synchronous and metachronous MPM were compared. Out of 6,545 cases, 72 patients (1.1%) including 39 males (54.2%) and 33 females (45.8%) were diagnosed as MPM, giving a male: female sex ratio of 1.2:1. Of these, there were 16 (22.2%) cases of synchronous MPM (7 males, 9 females), 55(76.4%) metachronous (31 males, 24 females), and 1 "mixed form". For first tumor diagnosis time, synchronous MPM patients generally presented later than the metachronous cases. The top three sites for malignancies with metachronous MPM were colorectum, head and neck, and lung, while for synchronous they were lung, colorectum and breast. Among MPM patients, the median survival time was 15.7 years and the 5-year survival was 56%, and there was statistical difference in MPM categories (P < 0.05). The median survival time was 17.3 years and 3.8 years for metachronous and synchronous MPM patients, respectively. In comparison with synchronous MPM patients, those metachronous had a longer survival. This studies increase understanding of the clinical features of Chinese MPM patients and suggest that those presenting with metachronous cancers have a higher incidence and a better prognosis.
Highlights
Multiple primary malignancies (MPM) is an infrequently occurring syndrome that is defined as two or more malignancies without subordinate relationship detected in the same or other organs of an individual patient
There is a scarcity of reports addressing patients with multiple primary malignancies (MPM), especially for Chinese cses
In comparison with synchronous MPM patients, those metachronous had a longer survival. This studies increase understanding of the clinical features of Chinese MPM patients and suggest that those presenting with metachronous cancers have a higher incidence and a better prognosis
Summary
Multiple primary malignancies (MPM) is an infrequently occurring syndrome that is defined as two or more malignancies without subordinate relationship detected in the same or other organs of an individual patient. Synchronous MPM refers to the malignancies occurring at the same time or within an interval of six months, while metachronous MPM refers to malignancies following in sequence and more than six months apart (Moertel, 1977). Of all the MPM patients, most are duplex primary malignancies. Improved understanding of the causes of MPM should help in protecting the patient from developing further tumors. The clinical characteristics and survival between synchronous and metachronous MPM were compared
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