Abstract
Results Five patients were included. In 3 patients, the diagnosis of HP preceded that of DM, while in 2 the opposite occurred. The average time between diagnosis of HP and DM was 80±24 months (range: 60-180 months). All patients used insulin. The mean dose was 0.71±0.63 IU/kg (range: 0.27-1.76 IU/kg). In four patients, we observed the use of other drugs (Metformin and glibenclamide) before insulin therapy was started, for a mean time of 46±45 months
Highlights
Hereditary pancreatitis (HP) is a rare autosomal dominant disease characterized by recurrent acute pancreatitis that progresses to chronic pancreatitis
In 3 patients, the diagnosis of HP preceded that of diabetes mellitus (DM), while in 2 the opposite occurred
Insulin was necessary in all cases, with a wide dosage variation between the different family members
Summary
Hereditary pancreatitis (HP) is a rare autosomal dominant disease characterized by recurrent acute pancreatitis that progresses to chronic pancreatitis. Common clinical manifestations are abdominal pain, disabsorptive syndrome due to exocrine dysfunction and diabetes mellitus (DM) due to damage to islet cells
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