Abstract
Although cranial autonomic symptoms (CAS) are typical in cluster headache (CH), some individuals with CH show no CAS during their headache attacks. Probable cluster headache (PCH) is a subtype of CH that fulfils all but one criterion of CH. This study aimed to investigate the frequency and clinical features of CH and PCH without CAS in comparison to those with CAS. We analysed data from the Korea Cluster Headache Registry, a prospective multicentre registry involving data from 16 hospitals. Of the 216 participants with CH and 26 with PCH, 19 (8.8%) and 7 (26.9%), respectively, did not have CAS. Participants with CH without CAS exhibited less severe anxiety (General Anxiety Disorder-7 score, median [interquartile range], 2.0 [1.0–6.0] vs 8.0 [3.0–12.0], p = 0.001) and depression (Patient Health Questionnaire-9 score, 3.0 [1.0–7.0] vs 7.0 [3.0–11.0], p = 0.042) than those with CAS. Among participants with PCH, headache intensity was less severe in participants without CAS than in those with CAS (numeric rating scale, 8.0 [7.0–8.0] vs 9.5 [8.0–10.0], p = 0.015). In conclusion, a significant proportion of participants with CH and PCH did not have CAS. Some clinical features of CH and PCH differed based on the presence of CAS.
Highlights
Cranial autonomic symptoms (CAS) are typical in cluster headache (CH), some individuals with CH show no cranial autonomic symptoms (CAS) during their headache attacks
None of the participants with CH or Probable cluster headache (PCH) without CAS had a sensation of fullness in the ear or forehead and facial flushing, which were included as CAS in ICHD-3 beta[11]
The main findings of the present study were as follows: (1) Approximately one-eleventh of participants with CH and a quarter of those with PCH did not have CAS; (2) Anxiety and depression were less severe in participants with CH without CAS than in those with CAS; and (3) Headache intensity was milder in participants with PCH without CAS than in those with CAS
Summary
Cranial autonomic symptoms (CAS) are typical in cluster headache (CH), some individuals with CH show no CAS during their headache attacks. A Portuguese study from a single university hospital reported in 2005 that headache intensity was less severe in individuals with CH without CAS than in those with C AS7. This study aimed to assess (1) the frequencies of CH and PCH without CAS among participants with CH and PCH and (2) the differences in the clinical features of participants with CH and PCH with and without CAS. For this purpose, we used data from the Korean Cluster Headache Registry (KCHR), a prospective, multicentre registry of CH
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
